The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion

Figure 4

EGF retained the differentiation potential that was impaired by TGF-β1 in hepatic oval cells. (a) Hepatocyte differentiation, detected by PAS staining, could be induced by sodium butyrate in control oval cells and cells allowed to 7-day EGF recover from TGF-β1 exposure whereas hepatocyte differentiation could not be seen in cells after 16-day TGF-β1 incubation. (b) Sodium butyrate increased more ALB and TAT transcription in control oval cells and EGF-reversion cells than in 16-day TGF-β1 treated cells.

(a)

(b)