Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation

Figure 1

Three regulatory modes of cellular functions. (a) The mechanical stimulation from substrates of different stiffness. (b) Signal activation from soluble factors bound to ECM. (c) Signal activation from adhesion molecules such as integrins. SF indicates soluble factor and GAG indicates glycosaminoglycan.