p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose <i>γ</i>-Irradiation

<div>Effects of oxygen levels on the number of repair foci in sham-irradiated and 4 Gy irradiated p53wt/wt mMSCs. (a) Sham-irradiated (0 Gy) <i>γ</i>H2AX foci formation under normoxic cultures (right upper image) and hypoxic cultures (left upper image) and additionally 90 min after exposure to 4 Gy <i>γ</i>-irradiation (lower images). (b) Quantification of <i>γ</i>H2AX foci in 50 p53wt/wt mMSC nuclei depicted as mean values ± standard error of the mean (3 biological replicates).</div>

Stem Cells International

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Figure 3: p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose <i>γ</i>-Irradiation 

Stem Cells International

p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation

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