Osteogenic Differentiation of Human Amniotic Fluid Mesenchymal Stem Cells Is Determined by Epigenetic Changes

Figure 5

Schematic representation of chromatin remodeling conducted by epigenetic changes during osteogenic differentiation of AF-MSCs. Certain chromatin regions changeover from suppressed, silenced state to open, actively transcribed state via histone modifications (reduction of repressive methylation of H3K27 and upregulation of activating acetylation of H3K9 and H4) and related enzymes expression (decrease of PRC2 complex components EZH2 and SUZ12 as well as HDAC1/HDAC2 and DNMT1). Notably only components investigated in this study are shown as many more enzymes and modifications are involved in global epigenetic network.