Biomaterial Applications in Cell-Based Therapy in Experimental Stroke

Table 1

Examples of biomaterials applications in experimental stroke.

Cells/growth factors	Species/stroke model	Biomaterial	Outcomes	References
hRecombinant osteopontin	Rats tMCAO	Gelatin type A microspheres	of infarct volume neurological deficits	Jin et al. 2014 [122]
rBMSCs	Rats pMCAO	N-Isopropyl- acrylamide polymer sheets	Improvement of motor function	Ito et al. 2014 [87]
Pegylated EGF and EPO	Mice focal ischemia endothelin-1	PEG microparticles; PLGA nanoparticles dispersed in a (HAMC) hydrogel	↓ of inflammation, ↓ of infarct volume	Wang et al. 2013 [99]
hNSC	Rats tMCAO	VEGF-PLGA microparticles	Neovascularization, angiogenesis	Bible et al. 2012 [123]
iPS-NPCs	Mice cortical photothrombotic	HA, acrylate	↑ of differentiation to neuroblast	Lam et al. 2014 [95]
hNSC	Rats tMCAO	Xenogeneic (ECM) bioscaffold	Formation of de novo tissue	Bible et al. 2012 [121]
ONO-1301	Rats tMCAO	Subcutaneous (PLGA) microspheres	Neuroprotection and ↓ side effects compared to OA	Hazekawa et al. 2012 [81]
HMGB1	Rats tMCAO	Gelatin microspheres	↓ infarct volume	Jin et al. 2011 [124]
EGF	Mice focal ischemia endothelin-1	PEG microparticles dispersed in a (HAMC) hydrogel	↑ neural stem/progenitor cells	Cooke et al. 2011 [125]
NSC	Rats tMCAO	Collagen type I matrix	↑ synapses and functional recovery	Yu et al. 2010 [57]
hVEGF	Rats tMCAO	Alginate hydrogel	↓ infarct volume; ↓ functional deficits	Emerich et al. 2010 [55]

MCAo p or t, permanent or transient middle cerebral artery occlusion; BMSCs, bone marrow stromal cells; EGF, epidermal growth factor; EPO, erythropoietin; SC, stem cells; PEG, polyethylene glycol; HAMC, hyaluronan methylcellulose; h, human; NSC, neural stem cells; VEGF, vascular endothelial growth factor, iPS, induced pluripotent stem; HA, hyaluronic acid; NPCs, neural pluripotent cells; PLGA, poly lactic-co-glycolic acid; OA, oral administration; HMGB1, high-mobility group box 1 protein; ECM, extracellular matrix.