Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats

Figure 1

Histological findings of pancreatic and pulmonary tissues after AP. The scale bars are equal to 100 μm in all of the images. (Normal pancreas) pancreatic acini of a control animal; the glandular architecture was entirely normal (H&E, ×200). (SAP 4 h pancreas) pancreatic interstitial edema and infiltration of a great deal of inflammatory cells 4 h after SAP (H&E, ×200). (SAP 8 h pancreas) necrosis of pancreatic acini and hemorrhage in parenchyma 8 h after SAP (H&E, ×200). (SAP 24 h pancreas) severe necrosis, hemorrhage, and infiltration of inflammatory cells 24 h after SAP; structure of pancreatic acini was damaged obviously (H&E, ×200). (Normal lung) pulmonary alveoli of a control animal (H&E, ×200). (SAP 24 h lung) interstitial edema and effusion in alveolar space 24 h after SAP (H&E, ×200). (SAP 7 d pancreas) seven days after SAP induction; pancreatic acini were replaced by granulation tissue and there was significant proliferation of condulets. Tubular complex formation could be found (H&E, ×200). (MAP 7 d pancreas) seven days after mild acute pancreatitis induction, pancreatic tissue almost recovered and no obvious necrosis or infiltration could be found (MAP was induced by repeated cerulein intraperitoneal injection in a previous study).