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Stem Cells International
Volume 2016, Article ID 7235757, 10 pages
http://dx.doi.org/10.1155/2016/7235757
Research Article

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins

1Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan
2Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan
3Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan
4Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
5Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan
6Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan

Received 24 December 2015; Accepted 28 March 2016

Academic Editor: Kaylene Young

Copyright © 2016 Hayato Fukusumi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Thomson, J. Itskovitz-Eldor, S. S. Shapiro et al., “Embryonic stem cell lines derived from human blastocysts,” Science, vol. 282, no. 5391, pp. 1145–1147, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Takahashi, K. Tanabe, M. Ohnuki et al., “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, vol. 131, no. 5, pp. 861–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Yu, M. A. Vodyanik, K. Smuga-Otto et al., “Induced pluripotent stem cell lines derived from human somatic cells,” Science, vol. 318, no. 5858, pp. 1917–1920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Okita, T. Yamakawa, Y. Matsumura et al., “An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells,” STEM CELLS, vol. 31, no. 3, pp. 458–466, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Nasu, M. Ikeya, T. Yamamoto et al., “Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin,” PLoS ONE, vol. 8, no. 1, Article ID e53771, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Osafune, L. Caron, M. Borowiak et al., “Marked differences in differentiation propensity among human embryonic stem cell lines,” Nature Biotechnology, vol. 26, no. 3, pp. 313–315, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. S.-C. Zhang, M. Wernig, I. D. Duncan, O. Brüstle, and J. A. Thomson, “In vitro differentiation of transplantable neural precursors from human embryonic stem cells,” Nature Biotechnology, vol. 19, no. 12, pp. 1129–1133, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Elkabetz, G. Panagiotakos, G. Al Shamy, N. D. Socci, V. Tabar, and L. Studer, “Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage,” Genes and Development, vol. 22, no. 2, pp. 152–165, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Falk, P. Koch, J. Kesavan et al., “Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons,” PLoS ONE, vol. 7, no. 1, Article ID e29597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Koch, T. Opitz, J. A. Steinbeck, J. Ladewig, and O. Brüstle, “A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 9, pp. 3225–3230, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. D.-S. Kim, J. S. Lee, J. W. Leem et al., “Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity,” Stem Cell Reviews and Reports, vol. 6, no. 2, pp. 270–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Wada, M. Honda, I. Minami et al., “Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells,” PLoS ONE, vol. 4, no. 8, Article ID e6722, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. S. M. Chambers, C. A. Fasano, E. P. Papapetrou, M. Tomishima, M. Sadelain, and L. Studer, “Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling,” Nature Biotechnology, vol. 27, no. 3, pp. 275–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Morizane, D. Doi, T. Kikuchi, K. Nishimura, and J. Takahashi, “Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells,” Journal of Neuroscience Research, vol. 89, no. 2, pp. 117–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Watanabe, M. Ueno, D. Kamiya et al., “A ROCK inhibitor permits survival of dissociated human embryonic stem cells,” Nature Biotechnology, vol. 25, no. 6, pp. 681–686, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Eiraku, K. Watanabe, M. Matsuo-Takasaki et al., “Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals,” Cell Stem Cell, vol. 3, no. 5, pp. 519–532, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. R. Stacpoole, B. Bilican, D. J. Webber et al., “Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen,” Nature Protocols, vol. 6, no. 8, pp. 1229–1240, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Koyanagi-Aoi, M. Ohnuki, K. Takahashi et al., “Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 51, pp. 20569–20574, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Imaizumi, Y. Okada, W. Akamatsu et al., “Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue,” Molecular Brain, vol. 5, article 35, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Ohta, T. Nihira, A. Uchino et al., “I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway,” Human Molecular Genetics, vol. 24, no. 17, pp. 4879–4900, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Kanemura, H. Mori, S. Kobayashi et al., “Evaluation of in vitro proliferative activity of human fetal neural stem/progenitor cells using indirect measurements of viable cells based on cellular metabolic activity,” Journal of Neuroscience Research, vol. 69, no. 6, pp. 869–879, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Shofuda, H. Fukusumi, D. Kanematsu et al., “A method for efficiently generating neurospheres from human-induced pluripotent stem cells using microsphere arrays,” NeuroReport, vol. 24, no. 2, pp. 84–90, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Adewumi, B. Aflatoonian, L. Ahrlund-Richter et al., “Characterization of human embryonic stem cell lines by the International Stem Cell Initiative,” Nature Biotechnology, vol. 25, no. 7, pp. 803–816, 2007. View at Publisher · View at Google Scholar
  24. C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, “NIH image to imageJ: 25 years of image analysis,” Nature Methods, vol. 9, no. 7, pp. 671–675, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Mori, K. Ninomiya, M. Kino-Oka et al., “Effect of neurosphere size on the growth rate of human neural stem/progenitor cells,” Journal of Neuroscience Research, vol. 84, no. 8, pp. 1682–1691, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Dehmelt, G. Poplawski, E. Hwang, and S. Halpain, “NeuriteQuant: an open source toolkit for high content screens of neuronal Morphogenesis,” BMC Neuroscience, vol. 12, article 100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. R.-H. Xu, R. M. Peck, D. S. Li, X. Feng, T. Ludwig, and J. A. Thomson, “Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells,” Nature Methods, vol. 2, no. 3, pp. 185–190, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Watanabe, D. Kamiya, A. Nishiyama et al., “Directed differentiation of telencephalic precursors from embryonic stem cells,” Nature Neuroscience, vol. 8, no. 3, pp. 288–296, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. Blauwkamp, S. Nigam, R. Ardehali, I. L. Weissman, and R. Nusse, “Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors,” Nature Communications, vol. 3, article 1070, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Kim, A. Doi, B. Wen et al., “Epigenetic memory in induced pluripotent stem cells,” Nature, vol. 467, no. 7313, pp. 285–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Lister, M. Pelizzola, Y. S. Kida et al., “Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells,” Nature, vol. 471, no. 7336, pp. 68–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. J. M. Polo, S. Liu, M. E. Figueroa et al., “Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells,” Nature Biotechnology, vol. 28, no. 8, pp. 848–855, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. M. N. Manuel, B. Martynoga, M. D. Molinek et al., “The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels,” Neural Development, vol. 6, article 9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Moya, J. Cutts, T. Gaasterland, K. Willert, and D. A. Brafman, “Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity,” Stem Cell Reports, vol. 3, no. 6, pp. 1015–1028, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Lee, S. M. Chambers, M. J. Tomishima, and L. Studer, “Derivation of neural crest cells from human pluripotent stem cells,” Nature Protocols, vol. 5, no. 4, pp. 688–701, 2010. View at Publisher · View at Google Scholar · View at Scopus