A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives

Table 2

Examples of microRNAs targeting BMP pathway components and their inhibition via anti-miR RNA interference.

miRNA	Target(s)/notes	Reference(s)	Anti-miR
miR-17-5p	Bmpr2, Smad7	[154, 155]	NR
miR-20a	Bmpr2, Bambi, Crim1	[154, 156]	[157]
miR-23b	Smad4, Smad5; also Smad3	[158]	NR
miR-26a	Smad1, Smad4, Tob1	[159–161]	[159, 160]
miR-27	Acvr2a; also Tgfβr1 and Smad2	[162]	NR
miR-30a/b/c/d	Bmp7, Smad1	[163, 164]	[164]
miR-100	Bmpr2	[165]	NR
miR-122	Hemojuvelin	[166]	[166]
miR-125	Bmpr2	[167]	[167]
miR-130a	Alk2	[168]	NR
miR-135b	Bmpr2, Smad5; also Alk4 and Tgfβr2	[169, 170]	NR
miR-140	Bmp2	[171]	NR
miR-145	Undetermined (possibly Bmp4 indirectly)	[172]	NR
miR-148a	ALK2	[173]	NR
miR-153	Bmpr2	[174]	NR
miR-155	Smad1, Smad5	[175, 176]	NR
miR-199a	Smad1	[177]	[177]
miR-200	Bmp4, indirectly	[178]	NR
miR-205	Smad1, Smad4	[179]	NR
miR-302	Bmpr2	[180]	NR
miR542-3p	Bmp7	[181]	NR

NR: not reported.