The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging

Table 2

The characterization of specific secretory proteins in PSC-CM.

Protein name	UniProtKB ID	Gene	Molecular function	Biological process	Subcellular location	Family	Function
Monocyte chemotactic protein 1	P13500	CCL2	Cytokine	Chemotaxis, inflammatory response	Secreted	Chemokine CC family	Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte antitumor activity
Kit ligand	P21583	KITLG	Growth factor	Cell adhesion	Cell membrane, cytoplasm, cytoskeleton, and membrane, secreted	SCF family	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and melanogenesis
Fibroblast growth factor 2	P09038	FGF2	Developmental protein, growth factor, mitogen	Angiogenesis, differentiation	Nucleus, secreted	Heparin-binding growth factors family	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation, and cell migration
Fibroblast growth factor 7	P21781	FGF7	Growth factor, mitogen	U/A	Secreted	Heparin-binding growth factors family	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation
Angiopoietin-1	Q15389	ANGPT1	Developmental protein	Angiogenesis, differentiation	Secreted	U/A	Plays an important role not only in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, and reorganization of the actin cytoskeleton, but also in the maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis
Placenta growth factor	P49763	PGF	Developmental protein, growth factor, mitogen	Angiogenesis, differentiation	Secreted	PDGF/VEGF growth factor family	Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration
Adrenomedullin	P35318	ADM	Hormone	U/A	Secreted	Adrenomedullin family	AM and PAMP are potent hypotensive and vasodilator agents. Numerous actions have been reported, most related to the physiologic control of fluid and electrolyte homeostasis
Plasminogen activator	P00749	PLAU	Hydrolase, protease, and serine protease	Blood coagulation, fibrinolysis, hemostasis, and plasminogen activation	Secreted	Peptidase S1 family	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin
Platelet-derived growth factor	P04085	PDGFA	Developmental protein, growth factor, mitogen	U/A	Secreted	PDGF/VEGF growth factor family	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival, and chemotaxis
Matrix metalloproteinase-1	P03956	MMP1	Hydrolase, metalloprotease, and protease	Collagen degradation, host-virus interaction	Extracellular matrix, secreted	Peptidase M10A family	Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X
Matrix metalloproteinase-9	P14780	MMP9	Hydrolase, metalloprotease, and protease	Collagen degradation	Extracellular matrix, secreted	Peptidase M10A family	Cleaves type IV and type V collagen into large C-terminal three-quarter fragments and shorter N-terminal one-quarter fragments