Research Article

Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction

Table 3

Changes in expression levels of genes involved in ECM remodeling four week after MI. Large changes in expression are demonstrated by arrows (↑ = 2–20x increase, ↑↑ = 20–50x increase, and ↑↑↑ = >50x change). Significance is denoted in brackets.

Gene nameBeadsBeads-MSCBeads-MSC-GLP-1
InfarctBorderRemoteInfarctBorderRemoteInfarctBorderRemote

Col1a1↑↑↑↑↑↑↑↑↑↑
Col3a1↑↑ ()
TIMP1↑ ()↑ ()
TIMP2↑ ()
MMP2↑↑↑↑↑↑↑↑
MMP9↑↑↑↑↑↑↑↑
TGF-β↑↑↑↑ ↑ ↑ ()↑↑