Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 7419389, 9 pages
http://dx.doi.org/10.1155/2016/7419389
Research Article

N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ1–42 via the CB2 Receptor

1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
2Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received 25 August 2015; Revised 16 November 2015; Accepted 1 December 2015

Academic Editor: Gary E. Lyons

Copyright © 2016 Wen-Qing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Gómez-Isla, R. Hollister, H. West et al., “Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease,” Annals of Neurology, vol. 41, no. 1, pp. 17–24, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Bucciantini, E. Giannoni, F. Chiti et al., “Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases,” Nature, vol. 416, no. 6880, pp. 507–511, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Mangialasche, A. Solomon, B. Winblad, P. Mecocci, and M. Kivipelto, “Alzheimer's disease: clinical trials and drug development,” The Lancet Neurology, vol. 9, no. 7, pp. 702–716, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Amrein, K. Isler, and H.-P. Lipp, “Comparing adult hippocampal neurogenesis in mammalian species and orders: influence of chronological age and life history stage,” European Journal of Neuroscience, vol. 34, no. 6, pp. 978–987, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Pluchino, L. Zanotti, M. Deleidi, and G. Martino, “Neural stem cells and their use as therapeutic tool in neurological disorders,” Brain Research Reviews, vol. 48, no. 2, pp. 211–219, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Yirmiya and I. Goshen, “Immune modulation of learning, memory, neural plasticity and neurogenesis,” Brain, Behavior, and Immunity, vol. 25, no. 2, pp. 181–213, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. Nagy, M. M. Esiri, and A. D. Smith, “Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions,” Acta Neuropathologica, vol. 93, no. 3, pp. 294–300, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. J. W. Shay, O. M. Pereira-Smith, and W. E. Wright, “A role for both RB and p53 in the regulation of human cellular senescence,” Experimental Cell Research, vol. 196, no. 1, pp. 33–39, 1991. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Micale, C. Mazzola, and F. Drago, “Endocannabinoids and neurodegenerative diseases,” Pharmacological Research, vol. 56, no. 5, pp. 382–392, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Piomelli, A. Giuffrida, A. Calignano, and F. R. de Fonseca, “The endocannabinoid system as a target for therapeutic drugs,” Trends in Pharmacological Sciences, vol. 21, no. 6, pp. 218–224, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Petrosino and V. Di Marzo, “FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels,” Current Opinion in Investigational Drugs, vol. 11, no. 1, pp. 51–62, 2010. View at Google Scholar · View at Scopus
  12. Y. G. Cao, X. Y. Mao, C. Y. Sun et al., “Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways,” Brain Research Bulletin, vol. 85, no. 6, pp. 396–402, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Babu, J.-H. Claasen, S. Kannan, A. E. Rünker, T. Palmer, and G. Kempermann, “A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus,” Frontiers in Neuroscience, vol. 5, article 89, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. O. M. E. Abdel-Salam, “Stem cell therapy for Alzheimer's disease,” CNS & Neurological Disorders—Drug Targets, vol. 10, no. 4, pp. 459–485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Qian, A. A. Davis, S. K. Goderie, and S. Temple, “FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells,” Neuron, vol. 18, no. 1, pp. 81–93, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. N. G. N. Milton, “Anandamide and noladin ether prevent neurotoxicity of the human amyloid-β peptide,” Neuroscience Letters, vol. 332, no. 2, pp. 127–130, 2002. View at Publisher · View at Google Scholar · View at Scopus