Cellular Reprogramming Using Defined Factors and MicroRNAs

Table 1

List of OstemiR and their potent targets. PTM, posttranslational modification factor.

	Growth factor	Receptor	Signal, PTM	Transcription factor	Epigenetic regulator	Cell cycle regulator	Others
miR-30a, miR-30d, miR-30e	Nov, Igf, Bdnf	Lrp6, LifR, Notch, Igf2R, Igf1R, Integrin a5/a4, Integrin b3	Senp5	Sox9, Runx2, Smad1/2, FoxO3, Klf9/11, Zeb2, Snai1, NcoA1, HoxB8, Lin28b	Tet1, Tet3, SirT1, Hdac5, Eed, Mbd6	Cyclin E2/T2/K, Cdk6	HspA5/Grp78
miR-30b, miR-30c	Spp1/Opn, Ccn2	Lrp6, LifR		Sox9, Runx2, Lin28a, hnRnpA3, Pcgf5, Zbtb41/44	SirT1, Eed		HspA5/Grp78
miR-21	TgfB1, Fgf1	Lrp6, TgfbR2, BmpR2, AcvR1c, LifR, ItgB8	Ski, Smad7	Sox2/5, Klf3/5/12, Msx1	Tet1		Reck, Timp3
miR-16/miR-503	Wnt3a/4, Fgf7, Ihh, VegfA, Igf1	BmpR1a, AcvR2b, InsR, Igf1R	Smad7, Smurf1, Smurf2	Sox5, Myb, MybL1, FosL1		Runx1T1, Cyclin E1/D1/D2/D3/T2/M2, Cdk5r1/6	Hspg2, Reck
miR-155	Gdf6, Fgf7	TgfbR2, AcvR2b, Lrp1b		Tcf4, Smad1/2, Klf3, Fos, Sp1/3	SirT1	Cyclin D1	SmarcAD1, claudin1
miR-541	Wnt11	Integrin α3		Baz1b, Sp1	Ago1		Adamts7, Timp2