Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent

Figure 2

Different gene expression profiles of neonatal and adult SSCs with germ cell-enriched and pluripotency associated genes. Adult SSCs were obtained from 7- and 12-week-old mice. (a) Dendrogram and (b) PCA demonstrate that neonate and adult SSCs are distinct and localize in separated trees in the dendrogram or areas in the PCA. (c) Heat map shows array of pluripotency and germ cell associated genes with a cluster of different populations of neonatal SSCs (coloured dark blue), while adult SSCs cluster from 7- and 12-week-old mice in a separate tree (coloured light blue and green).

(a)

(b)

(c)