Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration

Figure 1

EPC homing from a BM niche to the circulation. HSCs and EPCs interact with stromal niche cells via Notch signals. HIF-1α, stabilized from ischemic signals, promotes EPC homing-related cytokines, including VEGF and SDF-1.