Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 8352684, 7 pages
http://dx.doi.org/10.1155/2016/8352684
Review Article

The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

1Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy
2Animal Facility Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy
3Division of Radiology, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy

Received 18 November 2015; Revised 24 December 2015; Accepted 27 January 2016

Academic Editor: Hu Li

Copyright © 2016 Sabrina Bimonte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.