The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Table 2

The regulatory functions of miRNAs on PCSCs properties.

Upregulation of onco-miRNAs	Downregulation of tumor suppressor miRNAs	Potential targets	Biological PCSCs behavior	Reference
miR-21		PI3K/AKT	Proliferation and chemoresistance	[37–39]
	miR-200a/c	n-cadherin, ZEB 1	EMT, stemness maintenance	[40–42]
	miR-34	BCL2	Self-renewal	[43, 44]
	miR-143/miR-145	Kras	Cancer cell growth	[45]
	miR-1246	CCNG2	Chemoresistance and stemness	[46]