iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study

Figure 1

Melanin-laden cells are enriched in RPE compartments of aging RCS rat retinas. (a) Ultrastructural examinations from a RCS rat four weeks after implantation with iPS-RPE. Note RPE polarization between the choriocapillaris, Bruch’s membrane (BM), and the debris layer. (b–e) A panel of 2+-year-old uninjected (b) and iPSC-RPE injected (c–e) eyes with corneas and lenses removed. Note the broad distributions of pigmented zones. (f) Electron micrograph of the subretinal space of a 17-month-old uninjected RCS rat. Scale bars = 5 μm.

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