iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study

Table 1

Summary of the blood work performed on the iPSC-RPE injected animals. One-year- and 10-month-old rats are listed as 1 y 10 m. Slight or moderate. White blood cell count (WBC), red blood cell count (RBC), HGB (hemoglobin), hemocrit (HCT), mean corpuscle volume (MCV), mean corpuscle hemoglobin (MCH), mean corpuscle hemoglobin concentration (MCHC), red blood cell morphology (RBC Morph.), polychromasia (PC), anisocytosis (AN), reference range (Ref. range), platelet counts (Platelet Ct.), and platelet estimates (Platelet Est.).

(a)

Sex	Age	WBC	RBC	HGB	HCT	MCV	MCH	MCHC	RBC Morph.
M	1 y 10 m	5.3	8.3	18.3	52	63	19.7	31	Normal
M	1 y 10 m	5.9	8.6	16.8	52	60	19.6	32	PC
M	1 y 5 m	8.7	7.6	14.8	49	64	19.4	30	PC
M	1 y 5 m	4.5	8.8	16.4	53	60	18.7	31	Normal
M	1 y 5 m	4.5	8.7	16.3	52	60	18.7	31	PC
M	1 y 5 m	7	8.9	16.7	55	62	18.8	30	PC/AN
F	1 y 6 m	3.7	7.5	14.2	47	63	18.9	30	Normal
M	1 y 6 m	5.4	8.3	15.6	52	62	18.7	30	Normal
F	1 y 5 m	4.8	7.8	15	49	63	19.3	31	Normal
F	1 y 5 m	3.7	7.1	13.7	46	65	19.3	30	Normal
Ave.		5.4	8.2	15.8	51	62	19.1	31	n/a
Ref. range		5.5–11	5.5–10.5	10.6–17.2	33–50	47–66	15–23	31–38	n/a
Units		10^3/L	10^6/L	g/dL	%	fL	pg	g/dL	n/a

(b)

Sex	Age	Platelet Ct.	Platelet Est.	Neutrophils	Lymphocytes	Monocytes	Eosinophils
M	1 y 10 m	1101	Increased	1060 (20%)	4028 (76%)	106 (2%)	106 (2%)
M	1 y 10 m	377	Adequate	2537 (43%)	3127 (53%)	118 (2%)	118 (2%)
M	1 y 5 m	1251	Increased	5133 (59%)	3306 (38%)	174 (2%)	87 (1%)
M	1 y 5 m	1133	Increased	945 (21%)	3465 (77%)	45 (1%)	45 (1%)
M	1 y 5 m	1176	Increased	990 (22%)	3330 (74%)	45 (1%)	90 (2%)
M	1 y 5 m	1110	Adequate	2450 (35%)	4340 (62%)	70 (1%)	140 (2%)
F	1 y 6 m	1038	Adequate	1147 (31%)	2405 (65%)	74 (2%)	74 (2%)
M	1 y 6 m	1242	Adequate	1674 (31%)	3510 (65%)	108 (2%)	108 (2%)
F	1 y 5 m	817	Adequate	1632 (34%)	3072 (64%)	48 (1%)	48 (1%)
F	1 y 5 m	667	Adequate	925 (25%)	2664 (72%)	37 (1%)	74 (2%)
Units		10^3/L	/L	/L	/L	/L	/L