Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children

Table 3

Representative genes differentially expressed with higher expression levels in dental follicles than in the gingiva (absolute fold change > 4.0).

Functional category	Gene symbol	Biological process	Accession number	Absolute fold change	Standard deviation
Metabolism and catabolism	ALDH1L2	Carbon metabolic process	NM_001034173	19.63	5.13
	MOXD1	Histidine catabolic process	NM_015529	17.92	4.91
	ELOVL2	Fatty acid metabolic process	NM_017770	12.62	4.07
	FBXL7	Protein catabolic process	NM_012304	8.58	3.27
Protein modification and maintenance	ADAM12	Metalloendopeptidase activity	NM_003474	37.09	7.25
	MMP16	Metalloendopeptidase activity	NM_005941	24.32	5.82
	MMP2	Metalloendopeptidase activity	NM_004530	19.64	5.17
	MMP8	Metalloendopeptidase activity	NM_002424	11.86	3.89
	MMP13	Metalloendopeptidase activity	NM_002427	7.60	3.16
	ADAM22	Proteolysis	NM_021723	5.97	2.75
Structural process	COL11A1	Extracellular matrix organization	NM_001854	29.15	6.38
	MAP1B	Microtubule bundle formation	NM_005909	10.30	3.61
	FBN2	Anatomical structure morphogenesis	NM_001999	9.02	3.40
	LUM	Collagen fibril organization	NM_002345	8.68	3.32
Transport activity	KCNT2	Ion transport	NM_198503	11.30	3.80
	ABCC9	Potassium ion transport	NM_005691	11.18	3.77
	RHOBTB3	Retrograde transport	NM_014899	10.62	3.72
	SLC4A4	Sodium ion transport	NM_001098484	10.12	3.68
	HEPH	Copper ion transport	NM_138737	8.34	3.28
Developmental process	AMBN	Odontogenesis	NM_016519	117.54	16.99
	CDH11	Ossification	NM_001797	38.12	7.40
	ALPL	Biomineral tissue development	NM_000478	33.21	6.83
	ASPN	Bone mineralization	NM_017680	33.05	6.85
	FGF7	Embryonic development	NM_002009	29.53	6.44
	COL1A2	Skeletal system development	NM_000089	14.50	4.41
	RUNX2	Ossification	NM_001024630	13.85	4.23
	PDGFRB	Embryonic development	NM_002609	11.85	3.93
	WNT2	Mesenchymal cell proliferation	NM_003391	10.28	3.73
	BMP5	Ossification	NM_021073	7.13	3.28
	LEF1	Wnt receptor signaling pathway	NM_016269	5.83	2.66
	PAX3	Organ morphogenesis	NM_181457	4.70	2.38
	MSX1	Organ morphogenesis	NM_002448	4.23	2.24
Physiologic process	VAT1L	Oxidation reduction	NM_020927	12.30	3.98
	TFPI	Blood coagulation	NM_006287	9.49	3.49
	TPM1	Muscle contraction	NM_000366	8.78	3.30
	SOBP	Sensory perception	NM_018013	8.27	3.21
Nucleic acid synthesis and modification	EYA4	DNA repair	NM_004100	24.90	5.86
	NAP1L3	Nucleosome assembly	NM_004538	16.47	4.68
	SNRPN	RNA splicing	BC043194	5.05	1.58
Signal transduction and regulation	PDE7B	Signal transduction	NM_018945	22.99	5.59
	CHN1	Signal transduction	NM_018945	22.98	5.60
	LIFR	Cytokine-mediated signaling pathway	NM_002310	8.78	3.31
	FSTL1	BMP signaling pathway	NM_007085	8.75	3.31
Apoptosis	SEMA3A	Apoptosis	NM_006080	51.87	8.72
	PEG10	Apoptosis	NM_015068	21.89	5.43
	SULF1	Apoptosis	NM_001128205	11.18	3.77
	NELL1	Induction of apoptosis	NM_006157	8.67	3.27
Cell adhesion	OMD	Cell adhesion	NM_005014	40.83	7.69
	VCAN	Cell adhesion	NM_004385	35.76	7.25
	SPON1	Cell adhesion	NM_006108	32.63	6.78
Cell cycle and transcriptional regulation	MYEF2	Transcription	NM_016132	6.71	2.88
	SYCP2	Cell cycle	NM_014258	5.41	2.53
	APBB2	Cell cycle arrest	NM_004307	5.25	2.49
Immune and inflammatory process	TPST1	Inflammatory response	NM_003596	9.00	3.34
	PXDN	Immune response	NM_012293	8.89	3.40
	IFI44L	Immune response	NM_006820	6.01	2.79
	PECAM1	Phagocytosis	NM_000442	4.26	2.25
	COLEC12	Phagocytosis, recognition	NM_130386	4.23	2.22
Cytokine and chemokine activity	CXCL12	Chemotaxis	NM_000609	11.04	3.79
	SLIT3	Chemotaxis	NM_003062	8.94	3.34
	CMTM3	Chemotaxis	NM_144601	5.24	2.52
	STX2	Cytokinesis	NM_194356	4.39	2.27
	CCR1	Chemotaxis	NM_001295	4.31	2.36