The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs
The signs of ONFH in imaging and histopathology at 8th week after treatment. Axial T2-weighted MRI in SHAM operated group showed intra-articular effusion, irregular femoral head margin, and flattened and smaller femoral head (a). Axial T2-weighted MRI in MCSs group showed marked reduction in lesion size, profile rules, and comparatively smooth edge (b). The result from the volumetric analysis showed that the necrotic volume of femoral heads in MSCs group was smaller than that in SHAM operated group () (e). Histological findings show disordered trabeculae, incomplete, significant degeneration, and necrosis with slight fractures in SHAM operated group (c) after eight-week treatment whereas the morphological structure of the MSCs group relatively improved (d). Scale bar 100 μm. Black arrow shows the slight fracture and blue arrow shows the fat cell hypertrophy. Comparison of the empty lacunae rate between MSCs group and SHAM operated group, the empty lacunae rate in SHAM operated group was significantly higher than that of MSCs group after eight-week treatment () (f). The percentage of trabecular bone volume in MSCs group was significantly higher than that in SHAM operated group after eight-week treatment () (g).
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