Differentiation and Molecular Properties of Mesenchymal Stem Cells Derived from Murine Induced Pluripotent Stem Cells Derived on Gelatin or Collagen

Figure 3

Microarray analysis of iMSCs/G, iMSCs/C, BMMSCs, and iPSCs. (a) Hierarchical cluster analysis of iMSCs/G, iMSCs/C, BMMSCs, and iPSCs by selecting 50 genes with upregulation by 2-fold in BMMSCs relative to iPSCs. (b) Hierarchical clustering analysis of MSC-specific genes of iMSCs/G, iMSCs/C, BMMSCs, and iPSCs. (c-e3) Pairwise scatter plots comparisons of the gene expression profiles of iMSC/C versus iMSC/G (c), BMMSC versus iMSC/C (d1)/iMSC/G (d2), BMMSC versus iPSC (e1), iMSC/C/iPSC (e2), and iMSC/G/iPSC (e3). Diagonal lines indicate the boundaries of twofold changes in gene expression. Gene expression levels are shown on log₁₀ scale. MSC-specific genes: stars (★).