Three-Dimensional Aggregates Enhance the Therapeutic Effects of Adipose Mesenchymal Stem Cells for Ischemia-Reperfusion Induced Kidney Injury in Rats

Figure 4

2D AdMSCs or 3D aggregate preserves renal function and histology after IR. ((a)-(b)) Circulating levels of urea nitrogen (BUN) and creatinine (Cr) in different experimental groups ( in each group). (c) Representative images of HE staining of kidney sections in each experimental group, showing significantly higher degree of tubular damage including tubular necrosis, cast formation, dilatation of tubules, and loss of brush border in IR group. (d) Results of total histopathological scores reflecting tubular damage in each group. .

(a)

(b)

(c)

(d)