Stem Cells International / 2016 / Article / Tab 3 / Review Article
Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses Table 3 Characteristics of studies that compared ACI with MACT.
Study Year Study design Regions Number of patients FU Age Gender Locations Major assessments of efficacy Excellent Good Fair Poor Graft hypertrophy Frequency of reoperation Other assessments Bartlett et al. [21 ] 2005 RCT England ACI-C: 44 1 yr 33.7, 15–49 54/37 Knee MCS 10 16 10 8 4/44 4/44 ICRS, biopsy Manfredini et al. [34 ] 2007 CCS Italy ACI-C: 17 Mean, 48.5 mo. 32.3, 17–51 15/2 Knee HSS 9 6 2 0 NR NR ICRS, MRI, and biopsy Ferruzzi et al. [35 ] 2008 CCS Italy ACI-P: 48 5 yr 32.3 30/18 Knee IKDC 7 10 23 8 4/48 6/48 MRI, biopsy Zeifang et al. [20 ]
2010 RCT Germany ACI-P: 10 2 yr 29.5 16/5 Femoral condyle IKDC NR NR NR NR 7/9 1/10 Lysholm, SF-36, TAS, and MOCART Macmull et al. [36 ] 2012 CCS England ACI-C: 25 Mean, 40.3 mo. 34.6, 17–50 16/9 Patellae MCS 4 6 6 9 NR NR VAS, Bentley score Panagopoulos et al. [37 ] 2012 CCS England ACI-P: 11 Mean, 37.5 mo. 32.2, 18–43 8/3 Knee Lysholm 0 2 4 5 3/11 NR IKDC, TAS
FU: follow-up; RCT: randomized controlled trial; CCS: case-control study; ACI-C: autologous chondrocyte implantation with a flap made of collagen; ACI-P: autologous chondrocyte implantation with periosteal flap MACT: matrix-assisted autologous chondrocyte transplantation; MCS: Modified Cincinnati Rating System; ICRS: International Cartilage Repair score; HSS: Hospital for Special Surgery score; IKDC: International Knee Documentation Committee; MRI: magnetic resonance imaging; SF-36: Short-Form-36 Health Survey; MOCART: Magnetic Resonance Observation of Cartilage Repair; VAS: Visual Analogue Scale; TAS: Tegner Activity Score.
