Improvement of Liver Transplantation Outcome by Heme Oxygenase-1-Transduced Bone Marrow Mesenchymal Stem Cells in Rats

Figure 3

Histological sections of the rat liver and grading of ACR after LTx. (A) Normal saline group; (B) HO-1 group; (C) BMMSCs group; (D) HO-1/MSCs group. (H&E staining, 100x). (a) In the normal saline and HO-1 groups, ACR grading on day 7 was moderate to severe, with abundant mixed lymphocytes in the portal area, interlobular bile duct inflammation and damage, inflammatory cell infiltration in the vein area, and necrosis of liver cells. In the BMMSCs group, ACR grading was mild until day 7, was aggravated sharply after day 7, and was moderate to severe on day 14. ACR was attenuated in the HO-1/MSCs group and decreased at all time points, compared to control groups (). (b) Histogram of ACR grading ( in each group, the HO-1-transduced BMMSCs group compared to control groups). Data are expressed as the mean ± SD ().

(a)  

(b)