Modulation of Immunoregulatory Properties of Mesenchymal Stromal Cells by Toll-Like Receptors: Potential Applications on GVHD

Table 2

Gene and protein expression of Toll-like receptors MSCs from different sources.

Source	Gene expression				Protein expression
	TLR2	TLR3	TLR4	TLR9	TLR2	TLR3	TLR4	TLR9
AT	P [58, 60, 61, 65]	P [50, 58, 60, 61, 65]	P [50, 58, 60, 61, 65]	P [58, 60, 61, 65]	P [60, 65]	P [60, 61]	P [60, 61, 65]	P [60]
BM	P [61–64, 68]	P [50, 61–64, 68, 69]	P [50, 61–64, 68, 69]	A [63, 64]; P [61, 62, 68]	P [62, 63, 66]	P [61–64, 66, 68, 70]	P [61–64, 66, 70]	P [62, 66]
UC	P [59, 61, 71]	P [50, 59, 61, 71, 72]	A [61]; P [50, 59, 71, 72]	P [59, 61, 71]	A [59]; P	P [59, 61]	A [61]; P [59]	A [59]

Notes. presence or absence of Toll-like receptors: TLR2, TLR3, TLR4, and TLR9, evaluated at gene or protein expression levels on mesenchymal stromal cells from different sources. Gene expression was evaluated by techniques of quantitative PCR or reverse-transcription PCR, while protein expression was evaluated by western blot or flow cytometry. AT (adipose tissue), BM (bone Marrow), and UC (umbilical cord). P: presence; A: absence.