Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue

Figure 5

Expression of immunomodulators in passage 3 mesenchymal stromal/stem cells (MSCs). (A) Histograms of the proinflammatory cytokines IFNγ and TNFα and the immunosuppressive cytokines TGFβ1/2 and IL10 (black, isotype-matched control; blue, positive controls). MRC5 cells were used as negative control for all cytokines. This experiment was performed in triplicate. (B) Expression rate (%). (C) Cytokine secretion based on the results of MRC5 cells in (B) displayed as falling, + (expression), or − (no expression) signs. ++ indicates a significant increase relative to MRC5.