Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy

Table 1

The mean mRNA expression ratio of HER1, HER2, HER3, and HER4 receptors for the EGF system and the ligands AR, EPI, and HB for the parental cell line hMSC-TERT4 and the derived clonal cell line hMSC-TERT20-CE8 with the ability to form sarcoma-like tumours in mice. All expressions levels are normalized to reference gene B2M. The numbers in bold represent the gene that exhibits significant changes when comparing hMSC-TERT20-CE8 with the parental cell line hMSC-TERT4.

Gene	Mean expression ratio (95% CI)
	hMSC-TERT4			hMSC-TERT20-CE8
		Mean	95% CI		Mean	95% CI
HER1	6	3.11	(2.05; 4.17)	9	2.58	(2.12; 3.04)
HER2	6	4.59	(3.65; 5.53)	9	0.93	(0.66; 1.19)
HER3	9	0.76	(0.63; 0.88)	12	0.43	(0.32; 0.54)
HER4	6	0.10	(0.00; 0.19)	9	0.03	(0.01; 0.05)
AR	6	0.65	(0.43; 0.86)	9	40.09	(31.09; 49.01)
EPI	6	0.06	(0.00; 0.12)	9	28.64	(17.28; 39.99)
HB	6	6.65	(3.76; 9.54)	9	21.52	(13.27; 29.77)