Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells

<div>Differentiation of NSCs into oligodendrocytes in the presence of FTY720. (a) Representative images of differentiated oligodendrocytes in different groups. Matured oligodendrocytes are both Olig2 (Green) and CC1 (Red) positive. Parts of the Olig2+ cells in the control group did not express CC1 (yellow arrows) while more morphological matured (white arrows) oligodendrocytes were seen in higher FTY720 concentration groups. Bar = 50 <i>μ</i>m. ((b)-(c)) Quantification of the proportion of differentiated oligodendrocytes. <svg height="8.55521pt" id="M23" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" 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ANOVA, followed by Dunnett’s multiple comparison tests.</div>

Stem Cells International

fig4

Figure 4

Figure 4: Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells 