Research Article

Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

Table 2

Neural differentiation/development.

GeneEncoded proteinFold change

Neural stem cells
ABCG2ATP-binding cassette, subfamily G (WHITE), member 2 (junior blood group)−1.526
ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)−4.911
CDT1Chromatin licensing and DNA replication factor 1−1.528
EGFL7EGF-like-domain, multiple 73.132
EPHA2EPH receptor A2−1.529
ETV4ets variant 4−1.934
ETV5ets variant 5−2.844
−2.651
FABP7Fatty acid binding protein 7, brain−2.095

Neural differentiation
ATOH8Atonal homolog 8 (Drosophila)1.932
AXLAXL receptor tyrosine kinase2.015
CRIM1Cysteine-rich transmembrane BMP regulator 1 (chordin-like)1.999
CRLF1Cytokine receptor-like factor 12.382
DAB1Dab, reelin signal transducer, homolog 1 (Drosophila)−2.297
ELK3ELK3, ETS-domain protein (SRF accessory protein 2)−1.613
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2−4.767
GAP43Growth associated protein 431.613
GLDNGliomedin5.809
HMOX1Heme oxygenase (decycling) 11.884
KLF9Kruppel-like factor 91.592
Lmo3LIM domain only 31.542
MAP6Microtubule-associated protein 61.874
MYRFMyelin regulatory factor2.527
NEUROD4Neuronal differentiation 42.036
OLIG1Oligodendrocyte transcription factor 12.660
PvrPoliovirus receptor1.768
RGS4Regulator of G-protein signaling 41.955
S1PR1Sphingosine-1-phosphate receptor 15.073
SOCS2Suppressor of cytokine signaling 22.052
2.335
WIPF1WAS/WASL interacting protein family, member 11.587

Neural differentiation markers
CALB2Calbindin 21.616
CNP2′,3′-Cyclic nucleotide 3′-phosphodiesterase1.732
GFAPGlial fibrillary acidic protein2.239
MBPMyelin basic protein1.768
MturnMaturin, neural progenitor differentiation regulator homolog (Xenopus)1.853
OMGOligodendrocyte myelin glycoprotein−1.822
OPALINOligodendrocytic myelin paranodal and inner loop protein39.246
PLP1Proteolipid protein 11.630
S100BS100 calcium binding protein B−1.675
TUBB2ATubulin, beta 2A class IIa1.608
TUBB2BTubulin, beta 2B class IIb1.535
TUBB3Tubulin, beta 3 class III1.976

Synapse and neurotransmitters
ABAT4-Aminobutyrate aminotransferase−1.512
ADRA1DAdrenoceptor alpha 1D1.803
ADRA2AAdrenoceptor alpha 2A2.900
ADRA2BAdrenoceptor alpha 2B−2.093
CHRM2Cholinergic receptor, muscarinic 21.635
CHRM3Cholinergic receptor, muscarinic 3−1.715
CHRNA7Cholinergic receptor, nicotinic, alpha 7 (neuronal)1.772
COMTCatechol-O-methyltransferase1.515
DDCDOPA decarboxylase (aromatic L-amino acid decarboxylase)1.711
DNM3Dynamin 32.643
EPHA5EPH receptor A52.076
GRIA3Glutamate receptor, ionotropic, AMPA 3−1.528
GRIA4Glutamate receptor, ionotropic, AMPA 4−1.997
GRIK2Glutamate receptor, ionotropic, kainate 2−1.565
GRM5Glutamate receptor, metabotropic 5−1.600
HTR1B5-Hydroxytryptamine (serotonin) receptor 1B, G-protein-coupled−2.377
HTR2B5-Hydroxytryptamine (serotonin) receptor 2B, G-protein-coupled2.205
LRRTM2Leucine-rich repeat transmembrane neuronal 23.665
LRRTM3Leucine-rich repeat transmembrane neuronal 32.210
NTMNeurotrimin1.820
PENKProenkephalin3.478
PRR7Proline rich 7 (synaptic)1.788
SLC10A4Solute carrier family 10, member 41.824
1.867
SLITRK2SLIT and NTRK-like family, member 2−2.414
SLITRK6SLIT and NTRK-like family, member 61.672
STON2Stonin 24.054
STXBP3Syntaxin-binding protein 31.730
Stxbp3bSyntaxin-binding protein 3B1.637
SV2CSynaptic vesicle glycoprotein 2C1.929
SYT6Synaptotagmin VI2.571

Neurite outgrowth
ATF3Activating transcription factor 32.579
DOK4Docking protein 44.937
FEZ2Fasciculation and elongation protein zeta 2 (zygin II)1.547
NAV2Neuron navigator 21.647
NRCAMNeuronal cell adhesion molecule2.496
PLXNB3Plexin B31.739
RGMARepulsive guidance molecule family member a1.552
RNF165Ring finger protein 165−1.548
ROBO2Roundabout, axon guidance receptor, homolog 2 (Drosophila)−2.211
SEMA3BSema domain, immunoglobulin domain (Ig), short basic domain, secreted (semaphorin) 3B3.692
SEMA3ESema domain, immunoglobulin domain (Ig), short basic domain, secreted (semaphorin) 3E2.877
SEMA4FSema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F4.891
SEMA6ASema domain, transmembrane domain (TM), and cytoplasmic domain (semaphorin) 6A−1.707
SRGAP1SLIT-ROBO Rho GTPase activating protein 11.524
UNC5Bunc-5 homolog B (C. elegans)−1.927

Growth factors
ARTNArtemin2.423
FGF2Fibroblast growth factor 2 (basic)2.264
FGF5Fibroblast growth factor 57.704
GDF10Growth differentiation factor 10−2.361
GDF11Growth differentiation factor 111.604
GDNFGlial cell derived neurotrophic factor4.325
GFRA3GDNF family receptor alpha 31.707
METMET protooncogene, receptor tyrosine kinase6.680
NGFRNerve growth factor receptor1.728
NTRK3Neurotrophic tyrosine kinase, receptor, type 3−1.575
SNX16Sorting nexin 161.641
SPHK1Sphingosine kinase 11.704
SPRY1Sprouty homolog 1, antagonist of FGF signaling (Drosophila)−1.647