Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

Table 5

Wnt.

Gene	Encoded protein	Fold change
Wnt signaling cascade
FZD7	Frizzled class receptor 7	−2.271
LEF1	Lymphoid enhancer-binding factor 1	−2.680
LRP5	Low density lipoprotein receptor-related protein 5	−1.571
LRRK2	Leucine-rich repeat kinase 2	1.677
TCF19	Transcription factor 19	−2.217
F7L1	Transcription factor 7-like 1 (T-cell specific, HMG-box)	−1.762
WNT5A	Wingless-type MMTV integration site family, member 5A	−2.325
WNT7B	Wingless-type MMTV integration site family, member 7B	2.942
Target gene
ARL4C	ADP-ribosylation factor-like 4C	2.179
AXIN2	Axin 2	1.744
CCND1	Cyclin D1	−2.476
CSRNP1	Cysteine-serine-rich nuclear protein 1	1.822
RACGAP1	Rac GTPase activating protein 1	−3.201
SPRY2	Sprouty homolog 2 (Drosophila)	−1.771
SPRY4	Sprouty homolog 4 (Drosophila)	−2.771
WISP1	WNT1 inducible signaling pathway protein 1	2.489
Wnt antagonists/inhibitors
APOE	Apolipoprotein E	1.704
DKK2	Dickkopf WNT signaling pathway inhibitor 2	1.731
EDIL3	EGF-like repeats and discoidin I-like domains 3	2.258
FRZB	Frizzled-related protein	1.938
HIC1	Hypermethylated in cancer 1	−1.731
JADE1	Jade family PHD finger 1	−1.656
LRP4	Low density lipoprotein receptor-related protein 4	1.979
NARF	Nuclear prelamin A recognition factor	−1.699
NEDD4L	Neural precursor cell expressed, developmentally downregulated 4-like, E3 ubiquitin protein ligase	1.588
NKD1	Naked cuticle homolog 1 (Drosophila)	3.220
NOTUM	Notum pectinacetylesterase homolog (Drosophila)	2.631
NOV	Nephroblastoma overexpressed	2.050
PRICKLE1	Prickle homolog 1 (Drosophila)	1.536
TLE3	Transducin-like enhancer of split 3	1.714
TRIB2	Tribbles pseudokinase 2	−1.637
Wnt activators
DAAM2	Dishevelled associated activator of morphogenesis 2	−1.993
PSRC1	Proline/serine-rich coiled-coil 1	−2.235
TNIK	TRAF2 and NCK interacting kinase	1.677
TRAF4	TNF receptor-associated factor 4	−1.673