|
| Patients |
Type of graft | Substrate |
3T3s
used |
Animal Free
culturing conditions | GMP |
Success rate | 2-line visual improvement |
Subsequent surgery |
Complications | Follow-up (months) |
| Mean | Range |
|
| Ang et al. [38] | 1 | Allograft | HAM (denuded) | + | + | − | 100% (1/1) | 0% (0/1) | — | — | 48 | — |
|
| Baradaran-Rafii et al. [45] | 8 | Autograft | HAM (denuded) | − | − | − | 88% (7/8) | 63% (7/8) | KP (4) | Perforation (1) | 34 | 6–48 |
|
| Basu et al. [55] | 50 | Autograft | HAM | − | + | − | 66% (33/50) | 76% (38/50) | KP (8) | Bleeding (23), bacterial keratitis (1) | 28 | 12–90 |
|
| Daya et al. [34] | 10 | Allograft | 3T3s | + | − | − | 70% (7/10) | 33% (3/9) | KP (5), cataract (1), KLAL (5) | Infective keratitis (1) | 28 | 12–50 |
|
| Di Girolamo et al. [43] | 2 | Autograft | Siloxane Hydrogel CL | − | − | − | 100% (2/2) | 50% (1/2) | — | — |
10.5 | 8–13 |
|
| Di Iorio et al. [48] | 166 | Autograft | Fibrin | + | − | − | 80% (133/166) | — | KP (33) | — | — | >6 |
|
| Fatima et al. [41] | 1 | Autograft | HAM | − | − | − | 100% (1/1) | 100% (1/1) | KP (1) | — | 37 | — |
|
| Gisoldi et al. [46] | 6 | Autograft | Fibrin | + | − | + | 83% (5/6) | 83% (5/6) | KP (4), cataract (1) | — | 24 | 11–34 |
|
| Grueterich et al. [29] | 1 | Autograft | HAM | − | − | − | 100% (1/1) | 100% (1/1) | KP (1), cataract (1) | — | 21 | — |
|
| Kawashima et al. [40] | 6 | Autograft (2), allograft (4) | HAM (denuded) | + | + | − | 100% (6/6) | 67% (4/6) | KP (6), cataract (5) | CRVO (1) | 32 | 20–44 |
|
| Koizumi et al. [26] | 13 | Allograft | HAM (denuded) | + | + | − | 77% (10/13) | 38% (5/13) | — | Rejection (3), infection (1), conjunctival invasion (2), conjunctival fibrosis (1) | 11 | 6–13 |
|
| Koizumi et al. [27] | 3 | Allograft | HAM (denuded) | + | + | − | 100% (3/3) | 0% (0/2) | — | — | 6 | — |
|
| Kolli et al. [50] | 8 | Autograft | HAM | − | − | + | 100% (8/8) | 63% (5/8) | KP (1), graft redo (1) | — | 19 | 12–30 |
|
| Meller et al. [44] | 1 | Allograft | HAM | − | − | − | 100% (1/1) | 100% (1/1) | — | Perforation (1) | 31 | — |
|
| Nakamura et al. [32] | 3 | Allograft | HAM (denuded) | + | + | − | 100% (3/3) | 33% (1/3) | — | — | 13 | 12–14 |
|
| Nakamura et al. [33] | 1 | Autograft | HAM (denuded) | + | + | − | 100% (1/1) | 100% (1/1) | — | — | 19 | — |
|
| Nakamura et al. [36] | 9 | Autograft (2), allograft (7) | HAM (denuded) | + | + | − | 100% (9/9) | 67% (6/9) | — | Infective keratitis (1) | 14.6 | 6–20 |
|
| Pathak et al. [58] | 9 | Autograft | HAM | − | + | − | 56% (5/9) | 33% (3/9) | KP (1), graft redo (1), AMT (1) | — | 18.5 | 11–24 |
|
| Pauklin et al. [51] | 44 | Autograft (30), allograft (14) | HAM | − | − | − | 68% (30/44) | 73% (32/44) | KP (8), cataract (5) | Bleeding (1), perforation (2) | 28.5 | 9–72 |
|
| Pellegrini et al. [22] | 2 | Autograft | 3T3s | + | − | − | 100% (2/2) | 50% (1/2) | KP (1) | — | — | >24 |
|
| Prabhasawat et al. [54] | 19 | Autograft (12), allograft (7) | Ham (denuded) | − | + | − | 73.7% (14/19) | 68.4% (13/19) | KP (6), lid correction (3), cataract (3), tarsorrhaphy (1) | Infection (3), PED (3), symblepharon (1) | 26.1 | 6–47 |
|
| Rama et al. [28] | 18 | Autograft | Fibrin | + | − | − | 78% (14/18) | 33% (6/18) | KP (3) | Persistent inflammation with bleeding (4) | 17.5 | 12–72 |
|
| Rama et al. [49] | 107 | Autograft | Fibrin | + | − | + | 68% (73/107) | 54% (61/107) | KP (62), PTK (2) | Bleeding (12), inflammation (59), herpetic keratitis (3), blepharitis/epitheliopathy (35), residual fibrin (11) | 35 | 12–120 |
|
| Sangwan et al. [31] | 2 | Autograft | HAM | − | − | − | 100% (2/2) | 50% (1/2) | — | Recurrence (1) | 12 | — |
|
| Sangwan et al. [31] | 15 | Autograft (11), allograft (4) | HAM | − | − | − | 100% (15/15) | 87% (13/15) | KP (15) | Rejection (4), glaucoma (1) | 15.3 | 7–24 |
|
| Sangwan et al. [37] | 78 | Autograft | HAM | − | − | − | 73% (57/78) | 37% (18/49) | KP (19) | Phthisis (2), keratitis (2), glaucoma (2) | 18.3 | 3–40 |
|
| Sangwan et al. [52] | 200 | Autograft | Ham (denuded) | − | + | − | 71% (142/200) | 60.5% (121/200) | — | Bleeding (56), PED (13), corneal melting (5), bacterial keratitis (3) | 36 | 12–91 |
|
| Schwab [23] | 19 | Autograft (17), allograft (2) | HAM | + | − | − | 74% (14/19) | 16% (3/19) | Graft redo (1) | — | 10.5 | 2–24 |
|
| Schwab et al. [24] | 14 | Autograft (10), allograft (4) | HAM (denuded) | + | + | − | 71% (10/14) | 36% (5/14) | KP (1) | Epithelial loss (1), cyclosporine-related (2), infectious keratitis (1), pyogenic granuloma (1) | 13 | 6–19 |
|
| Sejpal et al. [57] | 107 | Autograft | HAM (denuded) | − | + | − | 49.5% (53/107) | 54.2% (58/107) | KP (19), lid or fornix correction (16) | Infection (7), inflammatory granuloma (4), glaucoma (1), corneal thinning (1), bleeding (1), panophthalmitis (1) | 41.2 | 12–118 |
|
| Sharma et al. [53] | 50 | Autograft (34), allograft (16) | HAM (denuded) | − | − | − | 74% (37/50) | 68% (34/50) | KP (4) | — | 11 | 1.5–25 |
|
| Shimazaki et al. [30] | 13 | Allograft | HAM (denuded) | − | − | − | 38.5% (5/13) | 76.9% (10/13) | — | Perforation (4), infection (2) | — | — |
|
| Shimazaki et al. [39] | 27 | Autograft (7), allograft (20) | HAM (denuded) | + | − | − | 59% (16/27) | 48% (13/27) | KP (8), limbal transplant (3) | Infection (1), ulceration (4), perforation (4) | 29.3 | 6–85 |
|
| Shortt et al. [42] | 16 | Autograft (9), allograft (7) | HAM (denuded) | − | − | + | 75% (12/16) | 22% (2/9) | Graft redo (1) | Infection (1), cyclosporin related (1), graft detachment (1) | 9.3 | 6–13 |
|
| Subramaniam et al. [56] | 40 | Autograft | HAM (denuded) | − | − | − | 45% (18/40) | — | KP (10) | — | 33.4 | 1–87 |
|
| Thanos et al. [47] | 1 | Autologous | HAM | − | − | − | 100% (1/1) | 100% (1/1) | — | — | 24 | — |
|
| Tsai et al. [25] | 6 | Autograft (3), allograft (3) | HAM (denuded) | − | − | − | 100% (6/6) | 50% (3/6) | — | — | 15 | 12–18 |
|
| Vazirani et al. [60] | 70 | Autograft | HAM (denuded) | − | − | − | 71% (49/70) | — | — | — | 17.5 | — |
|
| Zakaria et al. [59] | 18 | Autograft (15), allograft (3) | HAM (denuded) | − | + | + | 67% (12/18) | 28% (5/18) | KP (7) | — | 24 | 4–48 |
|
| Overall | 1164 | Autograft (1029), allograft (135) | | | | | 70.26% | 54.92% | | | 25.4 | 1–120 |
|
