Transcriptome Profiling of IL-17A Preactivated Mesenchymal Stem Cells: A Comparative Study to Unmodified and IFN-γ Modified Mesenchymal Stem Cells

Table 2

Differentially expressed genes (mapped by DAVID): MSC-17 versus UT-MSC.

Gene symbol	Gene name	mRNA Accession	Fold change	value
Upregulated genes
MMP13	Matrix metallopeptidase 13 (collagenase 3)	NM_002427	15.60	0.0021
C3	Complement component 3; NULL	NM_000064	11.56	0.0039
LBP	Lipopolysaccharide binding protein	NM_004139	5.35	0.0031
VMO1	Vitelline membrane outer layer 1 homolog (chicken)	NM_182566	4.07	0.0022
CH25H	Cholesterol 25-hydroxylase	NM_003956	3.99	0.0023
IL6	Interleukin 6 (interferon, beta 2); NULL	NM_000600	3.44	0.0083
ZC3H12A	Zinc finger CCCH-type containing 12A	NM_025079	3.09	0.0010
CCL2	Chemokine (C-C motif) ligand 2	NM_002982	3.08	0.0405
ZNF253	Zinc finger protein 253	NM_021047	2.82	0.0010
SAA1	Serum amyloid A1	NM_000331	2.72	0.0102
CXCL6	Chemokine (C-X-C motif) ligand 6	NM_002993	2.44	0.0014
MMP1	Matrix metallopeptidase 1 (interstitial collagenase)	NM_002421	2.40	0.0356
NFKBIZ	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; NULL	NM_031419	2.36	0.0232
MIRLET7A2	MicroRNA let-7a-2	NR_029477	2.30	0.0031
RBMY2EP	RNA binding motif protein, Y-linked, family 2, member E pseudogene	ENST00000444169	2.27	0.0278
CCL8	Chemokine (C-C motif) ligand 8	NM_005623	2.20	0.0012
STC1	Stanniocalcin 1	NM_003155	2.20	0.0023
SFRP4	Secreted frizzled-related protein 4	NM_003014	2.19	0.0136
SLC22A3	Solute carrier family 22 (extraneuronal monoamine transporter), member 3	NM_021977	2.15	0.0452
TTTY11	Testis-specific transcript, Y-linked 11 (nonprotein coding)	NR_001548	2.15	0.0252
STEAP2	STEAP family member 2, metalloreductase; NULL	NM_001244944	2.12	0.0225
SCARNA18	Small Cajal body-specific RNA 18	NR_003139	2.06	0.0254
LOC100287834	Uncharacterised LOC100287834	NR_028349	2.06	0.0328
Downregulated genes
RPS24	Ribosomal protein S24; NULL	NM_001142285	−2.01	0.0209
LOC100133299	GALI1870	AY358688	−2.03	0.0095
POU5F1	POU class 5 homeobox 1	ENST00000259915	−2.04	0.0129
TMEM171	Transmembrane protein 171	NM_173490	−2.05	0.0133
IGLJ2	Immunoglobulin lambda joining 2	ENST00000390322	−2.07	0.0252
ITGA6	Integrin, alpha 6; NULL	ENST00000264107	−2.11	0.0109
RNU7-25P	RNA, U7 small nuclear 25 pseudogene; RNA, U7 small nuclear 11 pseudogene	ENST00000516544	−2.16	0.0047
GTF2IRD2B	GTF2I repeat domain containing 2B	NM_001003795	−2.20	0.0040
SERTAD4	SERTA domain containing 4	ENST00000367012	−2.29	0.0470
TPTE	Transmembrane phosphatase with tensin homology	ENST00000415664	−2.85	0.0128