Research Article

Transcriptome Profiling of IL-17A Preactivated Mesenchymal Stem Cells: A Comparative Study to Unmodified and IFN-γ Modified Mesenchymal Stem Cells

Table 3

Top 30 differentially expressed genes: MSC-17 versus MSC-γ.

Gene symbolGene namemRNA AccessionFold change value

Upregulated genes
 MMP13Matrix metallopeptidase 13 (collagenase 3)NM_00242724.270.0009
 HIST1H2AIHistone cluster 1, H2aiNM_00350917.440.0005
 U3Small nucleolar RNA U3ENST0000039089313.960.0118
 ZNF25Zinc finger protein 25ENSG0000017539513.660.0008
 LRRC15Leucine rich repeat containing 15NM_00113505713.570.0005
 HIST1H3GHistone cluster 1, H3gNM_00353412.680.0008
 SNORD114-11Small nucleolar RNA, C/D box 114-11NR_00320412.330.0386
 HIST1H3BHistone cluster 1, H3bNM_00353711.200.0064
 U1U1 spliceosomal RNANONHSAT05497710.540.0017
 HIST1H1BHistone cluster 1, H1bNM_00532210.280.0003
 SCDStearoyl-CoA desaturase (delta-9-desaturase)NM_00506310.150.0008
 KRT16P4Keratin 16 pseudogene 4ENST000004538839.110.0122
 ADAM12ADAM metallopeptidase domain 12NM_0012889738.960.0031
 HIST1H2BMHistone cluster 1, H2bmNM_0035218.870.0125
 HIST1H3FHistone cluster 1, H3fNM_0210188.770.0081
 ADAM12ADAM metallopeptidase domain 12NM_0012889738.700.0121
 KIAA1199KIAA1199; NULLNM_0186898.480.0045
 COL10A1Collagen, type X, alpha 1NM_0004936.870.0136
 DHCR77-Dehydrocholesterol reductase; NULLNM_0013606.510.0022
 P4HA3Prolyl 4-hydroxylase, alpha polypeptide IIINM_1829046.490.0043
 LBPLipopolysaccharide binding proteinNM_0041396.110.0021
 HAS1Hyaluronan synthase 1NM_0015236.100.0038
 COL1A1Collagen, type I, alpha 1; NULLNM_0000885.940.000002
 NDNFNeuron-derived neurotrophic factorNM_0245745.750.0147
 ELNElastin; NULLNM_0005015.650.0014
 WISP1WNT1 inducible signaling pathway protein 1NM_0038825.610.0052
 ADAM12ADAM metallopeptidase domain 12; NULLNM_0034745.560.0008
 KDELR3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3NM_0166575.360.0085
 HIST1H3IHistone cluster 1, H3iNM_0035335.020.0014
 CNN1Calponin 1, basic, smooth muscleNM_0012994.690.00001
Downregulated genes
 HLA-DRAMajor histocompatibility complex, class II, DR alphaNM_019111−553.640.0005
 GBP4Guanylate binding protein 4NM_052941−244.270.0001
 HLA-DRAMajor histocompatibility complex, class II, DR alpha; NULLENST00000442960−188.100.00005
 CXCL9Chemokine (C-X-C motif) ligand 9NM_002416−96.440.00001
 IDO1Indoleamine 2,3-dioxygenase 1NM_002164−76.980.00004
 HLA-DRB3Major histocompatibility complex, class II, DR beta 3ENST00000307137−70.870.0024
 GBP5Guanylate binding protein 5NM_052942−65.020.000004
 SECTM1Secreted and transmembrane 1; NULLNM_003004−50.740.0001
 GBP2Guanylate binding protein 2, interferon-inducibleENST00000464839−41.550.00001
 HLA-DPA1Major histocompatibility complex, class II, DP alpha 1NM_001242524−40.790.0011
 IFIT3Interferon-induced protein with tetratricopeptide repeats 3NM_001031683−39.520.0011
 CIITAClass II, major histocompatibility complex, transactivatorNM_000246−37.920.000003
 GBP1Guanylate binding protein 1, interferon-inducibleNM_002053−35.790.0002
 PSAT1Phosphoserine aminotransferase 1NM_021154−31.200.0001
 HLA-DPB1NULLOTTHUMT00000310634−28.810.00002
 GBP1P1Guanylate binding protein 1, interferon-inducible pseudogene 1ENST00000513638−27.870.00001
 GCH1GTP cyclohydrolase 1NM_000161−26.740.0002
 PARP14Poly (ADP-ribose) polymerase family, member 14NM_017554−26.490.0008
 IRF1Interferon regulatory factor 1NM_002198−24.920.000003
 HLA-DOAMajor histocompatibility complex, class II, DO alphaNM_002119−24.000.00001
 RARRES3Retinoic acid receptor responder (tazarotene induced) 3NM_004585−23.100.0001
 LGALS17ACharcot-Leyden crystal protein pseudogeneENST00000412609−22.450.0003
 HLA-DOAMajor histocompatibility complex, class II, DO alphaNM_002119−21.850.00001
 SLC7A11Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11NM_014331−21.620.00004
 USP30-AS1USP30 antisense RNA 1ENST00000478808−20.000.0001
 HCP5HLA complex P5 (non-protein coding); NULLENST00000457127−19.900.0001
 ICAM1Intercellular adhesion molecule 1NM_000201−19.630.0001
 WARSTryptophanyl-tRNA synthetase; NULLNM_004184−19.410.0001
 APOL1Apolipoprotein L, 1; NULLNM_003661−19.360.00002
 ERVK-7Endogenous retrovirus group K, member 7; novel transcriptENST00000522373−18.930.0267
 HLA-DPB2Major histocompatibility complex, class II, DP beta 2 (pseudogene)NR_001435−18.910.00009