Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner

Figure 1

MSCs attenuate cisplatin-induced acute kidney injury. (a) Blood urea nitrogen (BUN) and plasma creatinine levels are evaluated. (b) Histological scores (ranging between 0 and 4) were determinated and calculated on the percentage of tubules affected (0 ≤ 10%, 1 = 10–25%, 2 = 26–50%, 3 = 51–75%, and 4 ≥ 75%). (c) Representative H&E- and PAS-stained mouse kidney. H&E staining images of kidney tissue samples are shown at the same magnifications (×200). Concentration of (d) cytokines, (e) kynurenine, and (f) NO in mice sera. (g) IL-6 and TNF-α gene expression in mouse kidneys. Values are mean ± SEM; mice/group. , .

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