Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner

Figure 2

MSCs significantly attenuate influx of immune cells and their capacity to produce nephrotoxic and inflammatory cytokines. Total number of (a) CD45+ leukocytes, (b) CD45+CD11b+ myeloid cells, CD45+F4/80+ macrophages, CD45+CD11c+ dendritic cells, CD45+CD11b+Ly6G+ neutrophils, CD45+CD4+ T helper cells, CD45+CD8+ cytotoxic T cells, (c) TNF-α+CD11c+ dendritic cells, (d) IFN-γ+CD4+ T helper cells, and IL-17+CD4+ T helper cells in cisplatin- and cisplatin + MSC-treated mice. (e) Total number and representative flow cytometry dot plots of IFN-γ- and IL-17-producing cytotoxic CD8+ T cells. Data presented as mean ± SEM; mice/group. , .

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