Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner

Figure 4

MSC-CM reduces influx of inflammatory DCs and CTLs in cisplatin-induced acute kidney injury and alters their cytokine profile. Total number of (a) IL-10-producing CD45+CD11c+ DCs, CD4+CD25+FoxP3+ T regulatory cells, (b) TNF-α+CD45+CD11c+ DCs, (c) IFN-γ- and IL-17-producing CD8+ CTL cells that infiltrated kidneys of the control and experimental animals. Representative flow cytometry dot plots are shown. Values are mean ± SEM; mice/group. , .

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(b)

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