Skeletal Muscle Cell Induction from Pluripotent Stem Cells

Figure 2

Positive and negative signals from surrounding tissues for embryonic myogenesis. Dermomyotome receives positive (Shh, Wnt1, Wnt3a, Wnt6, Wnt7a, Delta1, and Noggin) and negative (BMP4) signals from surrounding tissues (dorsal neutral tube, floor plate, notochord, dorsal ectoderm, and lateral mesoderm) to form myotomes. This occurs at the Notch1/2-positive dorsomedial lip of dermomyotome.