Effect of stress over neurogenesis mediated by astrocytes.
|Type of stress||Type of study||Cellular effect||Molecular mechanism||References|
|Acute and chronic induced by dexamethasone||In vivo||Growth inhibition of astrocytes||After inducing cell cycle exit by reduction of cyclin D1 and increase of p27|||
|In vitro||Inhibition of NSPC proliferation (cultured with CM of stressed astrocytes)||By altered expression of neurotrophic factors (BDNF, NGF) and mitogenic factors (BFGF, VEGF) and death-inducing factors (FasL, Trail, Tweak, and TNFα)|
|Acute induced by dexamethasone or corticosterone||In vitro||Inhibition of astrocytes proliferation||By inducing reduction of GR expression|||
|Chronic induced by administration of ACTH||In vivo||Inhibition of astrocytes proliferation||By inducing reduction of GR expression|
|Acute and chronic||In vivo||Regulation of mRNAs in a cell type-dependent fashion||By glucocorticoids receptors|||
|Acute||In vivo||Increase hippocampus cellular proliferation||Increase of astrocytes FGF2 expression|||