Stem Cells International / 2017 / Article / Tab 2

Review Article

Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes

Table 2

miRNA associated with neurogenesis present in astrocytes- and astrocytes-derived exosomes.

miRNAExpression levelCellular processMolecular targetReferences

miR-9OverexpressionReduces axonal branching and neurite outgrowthMAP1b[132]
miR-9Upregulation/overexpressionPromotes neuronal differentiationNotch signaling, several targets[133]
miR-9Upregulation/overexpressionPromotes neuronal differentiation and dendritic branching, inhibits migrationTLX, REST, Rap2a, and stathmin[134]
miR-9Upregulation/overexpressionSuppresses astrogliogenesisLifr-beta, Il6st (gp130), and Jak1 (jack/stat pathway)[135]
miR-9Upregulation/overexpressionPromotes neuronal differentiation and migrationTLX/Nre1, Foxg1, REST/NRSF, CoREST, Meis2, Gsh2, Islet1, Id4, and stathmin[136]
miR-9OverexpressionMediates neural differentiation of ES cellSTAT3[137]
miR-9OverexpressionPromotes neuronal differentiationFoxg1, Gsh2, SIRT1, and REST/NRSF[138]
miR-9OverexpressionInhibits NSPC proliferation and facilitates NSPC differentiationTLX[118]
miR-9OverexpressionInhibits NSPC proliferation and facilitates NSPC differentiationHes1 (notch signaling)[139]
miR-26aUpregulationInhibits spine enlargementRSK3[140]
miR-26aDownregulationPrevents axonal regenerationGSK3β[141]
miR-26bUpregulationPromotes neuronal differentiationCtdsp2[142]
miR-29aUpregulationIncrease axonal branchingDCX[143]
miR-34aUpregulationPromotes neural differentiation and synaptogenesisTAp73, synaptotagmin-1, and sintaxin-1A[144]
miR-34aUpregulationInhibits neuronal differentiation, promotes proliferationNumbl, NeuroD1, and Mash1[134]
miR-34aUpregulationPromotes apoptosis, inhibits cell cycle progression and synaptic developmentBCL-2, Cdk-4 Cyclin D2 synaptotagmin syntaxin-1A[134]
miR-34aUpregulationNegatively regulate neurite outgrowth and dendritic branching[134]
miR-125bUpregulationPromotes neuronal differentiationBMP/TGFβ signaling[133]
miR-125bUpregulationPromotes neuronal differentiationNestin[145]
miR-125bUpregulationInhibits NSPC proliferation and promotes differentiationMusashi1[146]
miR-129UpregulationDetermination of the bipolar cell identity in retinaXotx2, Xvsv1[147]
miR-135bUpregulation/OverexpressionPromotes neuronal inductionBMP/TGFβ signaling[148]
miR-145UpregulationPromotes neuronal differentiationOCT4, SOX2, and KLF4[149]
miR-145UpregulationPromotes neuronal differentiationSOX2, Lin28/let7[150]
miR-221DownregulatedNeurite guidance[151]
Let-7 familyUpregulationPluripotency inhibitor promoting neural lineage, promotes neuronal differentiationLin28[133]
Let-7 familyUpregulationPromotes NSPCs differentiationc-Myc, Lin28[136]
Let-7bUpregulationInhibits proliferation and promotes the differentiation of NSPCsTLX, Cyclin D1[152]
miR-543UpregulationPromotes neural stem cell differentiation and neuronal migrationN-Cadherin, TrappC8[153]

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