Review Article

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance

Table 3

miRNAs expressed in MSC-EVs.

Source of EVsmiRNAFunctionReference

Human bone marrow-derived MSCsmiRNA-199b, miRNA-218, miRNA-148a, miRNA-135b, miRNA-221Regulate osteoblast differentiation[49]
Rats bone marrow-derived MSCsmiRNA-133bContribute to neurite outgrowth[38]
Human bone marrow-derived MSCsmiRNA-15aInhibit the growth of multiple myeloma cells[50]
Porcine adipose tissue-derived MSCsmiRNA-148a, miR532-5p, miRNA-378, let-7fRegulate apoptosis, proteolysis angiogenesis, and cellular transport[48]
Human bone marrow-derived MSCsmiRNA-21, miRNA-34aRegulate cell survival and proliferation [41]
Human bone marrow-derived MSCsmiRNA-23bInduce dormant phenotypes[51]
Mouse bone marrow-derived MSCsmiRNA-16Target VEGF; suppress angiogenesis[52]
Human adipose-derived MSCsmiRNA-486-5p, miRNA-10a-5p, let-7a-5p, miRNA-10b-5p, miRNA-191-5p, miRNA-22-3p, miRNA-222-3p, miRNA-21-5p, let-7f -5p, miRNA-127-3p, miRNA-143-3p, miRNA-99b-5p, miRNA-100-5p, miRNA-92a-3p, miRNA-92b-3p, miRNA-146a-5p, miRNA-26a-5p, miRNA-4485, miRNA-146b-5p, miRNA-51a-3pPromote the migration; involved in replicative senescence, immune modulatory function;
regulate cell cycle progression and proliferation;
modulate angiogenesis
[53]
Human bone marrow-derived MSCsmiRNA-143-3p, miRNA-10b-5p, miRNA-486-5p, let-7a-5p, miRNA-22-3p, miRNA-21-5p, miRNA-222-3p, miRNA-28-3p, miRNA-191-5p, miRNA-100-5p, miRNA-99b-5p, miRNA-92a-3p, miRNA-127-3p, let-7f-5p, miRNA-92b-3p, miRNA-423-5p, let-7i-5p, miRNA-10a-5p, miRNA-27b-3p, miRNA-125b-5pPromote the migration; involved in ASC replicative senescence, immune modulatory function;
regulate cell cycle progression and proliferation;
modulate angiogenesis
[53]