Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats

Figure 5

Hepatogenic differentiation of transplanted hPMSCs in rat livers (20x). Immunohistochemistry staining for human hepatic markers ALB, AFP, and CK18, light-brown coloration in cells means the positive staining results. Group III as a negative control; PC: human liver as positive control for ALB and CK18 and human liver cancer as a positive control for AFP; group II: fibrotic animals transplanted with hPMSCs and sacrificed one week, four weeks, eight weeks, or twelve weeks after transplantation (1 w, 4 w, 8 w, or 12 w). Scale bars: 100 μm.