Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke

Figure 2

The impact of delivery routes on the therapeutic effect of ADSC-E during stroke. tMCAO was induced using SD rat. Protein extracts from ADSCs (ADSC-E) were injected either through IV, IC, or IP after the operation. (a) The neurological deficits were graded based on mNSS scaling system (/group). (b, c) TTC staining was used to quantify the volume of infarct area at either Day 1 (/group) (b) or Day 7 (/group) (c). (d, e) TUNEL staining was used to measure apoptotic neurons. Scale bars: 100 um (e). Five sections from each mouse were selected (/group). For each section, TUNEL positive neural cells were counted from 3 separated yields. ANOVA was used to analyze the data. , , and .

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