Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2017, Article ID 2153629, 11 pages
https://doi.org/10.1155/2017/2153629
Research Article

Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke

1Department of Neurosurgery, The First Affiliate Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
2Neuroinflammation Unit, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
3Department of Immunology, Harbin Medical University, Harbin, Heilongjiang 150086, China
4Department of Neurosurgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, China

Correspondence should be addressed to Hongwei Xu; moc.liamtoh@65iewgnoh and Lixian Li; moc.anis@ydhzxll

Received 5 September 2016; Revised 21 November 2016; Accepted 27 November 2016; Published 7 February 2017

Academic Editor: Marc L. Turner

Copyright © 2017 Kai Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” The Lancet Neurology, vol. 8, no. 4, pp. 355–369, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Emberson, K. R. Lees, P. Lyden et al., “Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials,” The Lancet, vol. 384, no. 9958, pp. 1929–1935, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. W. J. Powers, C. P. Derdeyn, J. Biller et al., “2015 American Heart Association/American stroke association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American stroke association,” Stroke, vol. 46, no. 10, pp. 3020–3035, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Hao, Z. Zou, H. Tian, Y. Zhang, H. Zhou, and L. Liu, “Stem cell-based therapies for ischemic stroke,” BioMed Research International, vol. 2014, Article ID 468748, 17 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. A.-Z. Chen, N. Liu, H. Huang, F.-F. Lin, D.-S. Liu, and X.-H. Lin, “Outgrowth of neuronal axons on adipose-derived stem cell transplanting for treatment of cerebral infarction in rats,” Chinese Journal of Cellular and Molecular Immunology, vol. 27, no. 8, pp. 868–871, 2011. View at Google Scholar · View at Scopus
  6. S. Leu, Y.-C. Lin, C.-M. Yuen et al., “Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats,” Journal of Translational Medicine, vol. 8, article no. 63, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Jeon, K. Chu, S.-T. Lee et al., “Neuroprotective effect of a cell-free extract derived from human adipose stem cells in experimental stroke models,” Neurobiology of Disease, vol. 54, pp. 414–420, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. H. S. Nam, I. Kwon, B. H. Lee et al., “Effects of mesenchymal stem cell treatment on the expression of matrix metalloproteinases and angiogenesis during ischemic stroke recovery,” PLoS ONE, vol. 10, Article ID e0144218, 2015. View at Google Scholar
  9. H.-W. Du, N. Liu, J.-H. Wang, Y.-X. Zhang, R.-H. Chen, and Y.-C. Xiao, “The effects of adipose-derived stem cell transplantation on the expression of IL-10 and TNF-alpha after cerebral ischaemia in rats,” Chinese Journal of Cellular and Molecular Immunology, vol. 25, no. 11, pp. 998–1001, 2009. View at Google Scholar · View at Scopus
  10. M. Gutierrez-Fernandez, B. Rodríguez-Frutos, J. Ramos-Cejudo et al., “Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats,” Journal of Translational Medicine, vol. 13, no. 1, article no. 46, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Gutiérrez-Fernández, L. Otero-Ortega, J. Ramos-Cejudo, B. Rodríguez-Frutos, B. Fuentes, and E. Díez-Tejedor, “Adipose tissue-derived mesenchymal stem cells as a strategy to improve recovery after stroke,” Expert Opinion on Biological Therapy, vol. 15, no. 6, pp. 873–881, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Jeon, K. Chu, S.-T. Lee et al., “A cell-free extract from human adipose stem cells protects mice against epilepsy,” Epilepsia, vol. 52, no. 9, pp. 1617–1626, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Im, J. Ban, J. Lim et al., “Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease,” PLoS ONE, vol. 8, no. 4, Article ID e59438, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J.-J. Ban, S. Yang, W. Im, and M. Kim, “Neurogenic effects of cell-free extracts of adipose stem cells,” PLoS ONE, vol. 11, no. 2, Article ID e0148691, 2016. View at Publisher · View at Google Scholar
  15. K. Kingwell, “Epilepsy: extract from human stem cells shows promise in mouse model of epilepsy,” Nature Reviews Neurology, vol. 7, no. 10, p. 536, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. N. G. Campbell and K. Suzuki, “Cell delivery routes for stem cell therapy to the heart: current and future approaches,” Journal of Cardiovascular Translational Research, vol. 5, no. 5, pp. 713–726, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. T. J. Kean, P. Lin, A. I. Caplan, and J. E. Dennis, “MSCs: delivery routes and engraftment, cell-targeting strategies, and immune modulation,” Stem Cells International, vol. 2013, Article ID 732742, 13 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. S. K. Kang, D. H. Lee, Y. C. Bae, H. K. Kim, S. Y. Baik, and J. S. Jung, “Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats,” Experimental Neurology, vol. 183, no. 2, pp. 355–366, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Xiong, A. Mahmood, and M. Chopp, “Animal models of traumatic brain injury,” Nature Reviews Neuroscience, vol. 14, no. 2, pp. 128–142, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Gutiérrez-Fernández, B. Rodríguez-Frutos, J. Alvarez-Grech et al., “Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats,” Neuroscience, vol. 175, pp. 394–405, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Huang, D. He, G. Kleiner, and J. Kuluz, “Neuron-like differentiation of adipose-derived stem cells from infant piglets in vitro,” Journal of Spinal Cord Medicine, vol. 30, no. 1, pp. S35–S40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Tian, J. Zhou, J. Wang et al., “Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia,” Neural Regeneration Research, vol. 7, no. 25, pp. 1992–1999, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. L. E. Fox, J. Shen, K. Ma et al., “Membrane properties of neuron-like cells generated from adult human bone-marrow-derived mesenchymal stem cells,” Stem Cells and Development, vol. 19, no. 12, pp. 1831–1841, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Paul, I. Özen, N. S. Christophersen et al., “The adult human brain harbors multipotent perivascular mesenchymal stem cells,” PLoS ONE, vol. 7, no. 4, Article ID e35577, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Egashira, S. Sugitani, Y. Suzuki et al., “The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model,” Brain Research, vol. 1461, pp. 87–95, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. A. J. Nauta and W. E. Fibbe, “Immunomodulatory properties of mesenchymal stromal cells,” Blood, vol. 110, no. 10, pp. 3499–3506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Leto Barone, S. Khalifian, W. P. A. Lee, and G. Brandacher, “Immunomodulatory effects of adipose-derived stem cells: fact or fiction?” BioMed Research International, vol. 2013, Article ID 383685, 8 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Xu, P. Yu, X. Han et al., “TGF-β promotes immune responses in the presence of mesenchymal stem cells,” Journal of Immunology, vol. 192, no. 1, pp. 103–109, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. Q.-F. Kong, B. Sun, S.-S. Bai et al., “Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-β,” Journal of Neuroimmunology, vol. 207, no. 1-2, pp. 83–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. Q.-F. Kong, S. Bo, G.-Y. Wang et al., “BM stromal cell sameliorate experimental autoimmune myasthenia gravis by altering the balance of Th cells through the secretion of IDO,” European Journal of Immunology, vol. 39, no. 3, pp. 800–809, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Hegyi, G. Kudlik, É. Monostori, and F. Uher, “Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells,” Biochemical and Biophysical Research Communications, vol. 419, no. 2, pp. 215–220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Rozenberg, A. Rezk, M.-N. Boivin et al., “Human mesenchymal stem cells impact Th17 and Th1 responses through a prostaglandin E2 and myeloid-dependent mechanism,” Stem Cells Translational Medicine, vol. 5, no. 11, pp. 1506–1514, 2016. View at Publisher · View at Google Scholar