Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells

Figure 7

rMAPC acquire a migratory phenotype in response to SN of LPS-activated macrophages. (a) rMAPC migration towards SN of ±LPS-activated macrophages. The results are presented as percentage of area covered from the migrated fraction. A positive control rMAPC medium was used. Asterisks () indicate statistical significant differences. (positive control versus SN of naïve macrophages; ). Mean values ± SEM are from 7 independent experiments, with duplicates per experiment. (b) CCR1 and (c) CCR3 mRNA expression in rMAPC treated with SN of LPS-activated macrophages, SN of naïve macrophages, or LPS (). The results are shown as fold differences in comparison to the SN of naïve macrophages. Mean values ± SEM. Asterisks () indicate statistical significant differences. Data were analyzed with one-way ANOVA followed by Dunnett’s multiple comparison test. and .

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