Research Article

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation

Table 3

Genes regulated by PEMF in differentiating hBMSCs. Cells were from a normal 27-year-old female. Total RNA was isolated at day 23 of PEMF treatment. Analysis by Student’s t-test.

Gene symbolGene titleFold-change
(Avg PEMF versus avg controls)
p

Transcriptional regulator, RNA metabolism, and RNA transport
SPENSpen homolog, transcriptional regulator (Drosophila)
FOXO3, FOXO3BForkhead box O3; forkhead box O3B pseudogene
MIR21MicroRNA 21

Metabolic process
AKT3v-akt murine thymoma viral oncogene homolog 3

Growth factor and regulator
TBRG1Transforming growth factor beta regulator 1

Receptor
LEPRLeptin receptor

Cell adhesion, motility, and cytoskeletal
ARPC5Actin related protein 2/3 complex, subunit 5, 16 kDa
FBN2Fibrillin 2

Signaling transduction, pathway
THBS1Thrombospondin 1