Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons

<div>Heatmap of signal factor secretion by 2D-MSCs and 3D-MSCs cultured at different conditions. Six signal factors, IL-1Ra, IL-7, IL-16, MCP-3, TGF<i>β</i>3, and VEGF, were detected only under 3D culture conditions. 5 signal factors, IL-6, MCP-1, LIF, G-CSF, and SDF-1<i>α</i>, were higher in conditioned medium from all 3D culture conditions compared to the 2D culture condition. Two signal factors, TGF<i>β</i>1 and TGF<i>β</i>2 had decreased levels in conditioned media from 3D culture conditions compared to the 2D culture condition.</div>

Stem Cells International

fig3

Figure 3

Figure 3: Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons 

Figure 3 | Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons 