Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons

Figure 5

Heatmap of signal factor secretion by MVs derived from 2D-MSCs or 3D-MSCs cocultured with 661W cells. (a) 3D-MSC-MVs possessed enhanced capability of promoting signal factors secretion compared to 2D-MSC-MVs. SCGF-β, VEGF, and LIF expression levels are increased in a time dependent manner in supernatants from 661W-3D-MSC-MVs cocultured systems (b, c, d). denotes significant differences of value less than 0.05.

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