Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle

<div>The expression pattern of sFRP4 in mouse hair follicle during hair cycling. (a) Immunostaining shows sFRP4 expression in dorsal skin of C57BL/6 mice at P30 (early anagen), P35 (mid-anagen), P45 (catagen), and P56 (telogen). The lower panels show the higher power view of the upper panels. (b) Schematic of sFRP4 expression pattern in hair follicle. Epi: epidermis; SG: sebaceous gland; Bu: bulge; DP: dermal papilla; HG: hair germ; IRS: inner root sheath; ORS: outer root sheath. Bars: 50 <i>μ</i>m.</div>

Stem Cells International

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Figure 1

Figure 1: Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle 