Stem Cells International / 2017 / Article / Fig 2

Research Article

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis

Figure 2

Rats received an intra-articular injection of 1.5 × 106 late passage mouse mesenchymal stem cells (mMSCs) from the bone marrow of Balb/c mice in 50 μL serum-free medium (SFM) or 50 μL SFM (vehicle) on day 14 post MNX surgery. (a) Intra-articular injection of MSCs significantly altered MNX-induced changes in the weight-bearing asymmetry. (b) Paw withdrawal thresholds in MNX rats were unaltered by the treatment. Data are expressed as a % of the mean MNX-SFM AUC for three timepoints (31, 35, and 38 days) postsurgery. Statistical analysis used a Mann–Whitney nonparametric unpaired t-test. Data are mean ± SEM, MNX-SFM (), MNX-MSC (). WB: weight-bearing asymmetry; PWT: paw withdrawal thresholds. MNX-MSC versus MNX-SFM.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.