Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis

Figure 5

(a): Sagittal MRI scans; Location of SiMAG-labelled cells are depicted as areas of hypointense signal loss and highlighted by the red ring over the synovial cavity. (b) Corresponding histological sections. Fluorescent images correspond to location marked X on H&E images (inset). Implanted DiI-labelled MSCs are shown in red whilst all native materials are show by DAPI in blue. (c) Corresponding MRI signal loss profile. Groups include (i) SiMAG-labelled MSCs (MSC-MNP), (ii) MSCs only (MSC-VEH), and (iii) serum-free media. T: tibia; F: femur; S: synovial lining; M: meniscus. Scale bars = 100 μm.